Over the past few decades, our understanding of nutrition has grown enormously. We’ve learned that many people are not getting vitamins and minerals they need from food so supplements have become a popular option to fill in the gaps. Different vitamins and minerals play unique roles in the body, but did you know that taking them together can can maximize their benefits?

Here is where synergy comes in. Synergy is the idea that two or more substances provide a combined effect greater than the sum of their parts. Of course, the best way to get a balanced intake of nutrients is through a varied diet; however, this is not always possible with our busy, modern-day lifestyles. Supplements therefore provide a beneficial way supplement any gaps you may have by boosting nutrient intakes. Both food and supplements can contribute to nutritional synergy (1).

PurePharma-3 is the total reinvention of the traditional multivitamin. It’s a monthly health supplement package containing three of our products: O3M3 and D3 in convenient daily dose packets. What really sets PurePharma-3 apart from conventional multi-vitamins is the quality of its ingredients and the higher, optimum doses. By contrast, ingredients found in common multivitamins are often cheap; poor quality; and are packaged in less than optimum amounts.

PurePharma-3 simply addresses the three main deficiencies in Western diets, providing  high-dose vitamin D, omega-3 and magnesium, in addition to zinc and vitamin B6 that is designed to be easily absorbed. The combined elements of PP3 work collectively to boost the healthful effects of each other, as well as to help the absorption and function of other nutrients obtained from food.

Vitamin D3

Vitamin D is considered not just a vitamin but also a hormone, as not only is it found in food, but it’s also generated through exposing your skin to the sun. In fact, vitamin D3 is the most common vitamin deficiency found in populations worldwide. The vast majority of people of working age in advanced economies sit in offices throughout the daylight hours and never get to reap the benefits of exposure to the sun.

Furthermore, very few foods (apart from oily fish, eggs, some mushrooms and fortified foods) contain natural vitamin D. Vitamin D deficiency can produce a wide range of symptoms which can affect bone health, immune system, cardiovascular system and cognitive ability. It even plays a role in the prevention and treatment of type I and type II diabetes. But a supplement such as PurePharma D3, provides an easy solution to deficiency by allowing you to obtain the recommended level of this important vitamin.

Vitamin D is known for working with magnesium, Vitamin A, Vitamin K, and zinc in the body (2).

Additionally, the relationship of Vitamin D and calcium is well established – vitamin D helps with the absorption of calcium in the digestive system and consequently helps maintain bone health. Zinc, too, is involved in bone creation by helping form bones and helping with collagen synthesis (3).

Mineral M3

Our Mineral M3 gives you a daily dose of magnesium and zinc. It also contains vitamin B6 and malic acid to help your body absorb these essential minerals.

Magnesium synergy 

Magnesium deficiency is incredibly common and is second only to Vitamin D deficiency amongst populations worldwide. Magnesium naturally occurs in green vegetables such as spinach and kale, as well as in nuts and seeds. It has a huge range of functions within your body, including muscle function, nerve function and keeping your heart healthy. Not only that, but magnesium helps your body to utilize other vitamins and minerals, such as phosphorus, sodium, potassium and vitamin D. These all work synergistically to help maintain healthy bones and keep your heart working in tip-top condition.

Magnesium helps convert vitamin D to its active form. (4). Additionally, magnesium deficiency is associated with disruptions to the parathyroid gland, which leads to a disruption in the release of parathyroid hormone (PTH). This alongside Vitamin D, is responsible for handling calcium in your body. Vitamin D and magnesium are therefore somewhat of a dream team when it comes to synergy.

Magnesium and vitamin B6 are known to work together, too. They have been shown to work in tandem to reduce anxiety (5), particularly in some pre-menstrual women.

Zinc synergy 

In addition to the beneficial effects on bone health, zinc also regulates protein synthesis in your muscle tissue and therefore contributes to muscle growth. Additionally, zinc is involved in moving vitamin A into your blood (6), where it plays a role in your reproductive health, maintaining your eye health and immune system.

Vitamin B6 plays a role in over 100 enzymatic reactions that keep your body functioning. Because of this, it’s really important for you to get adequate B6. There is a link between zinc and vitamin B6. Vitamin B6 requires a zinc-dependent enzyme for it to be changed to a usable form. So, a low intake of zinc may contribute to a vitamin B6 deficiency, leading to symptoms of fatigue, rashes and a compromised immune system.


Omega-3 works in synergy with B vitamins including Vitamin B6 and B12. Intakes of B vitamins alongside omega-3 have been shown to combat inflammation. So when you’re deficient in these, you are more likely to have more inflammation. To learn more about inflammation and ways to reduce it, click here.

Additionally, omega-3 works with magnesium to maximize heart health and lower blood pressure. It also works together with vitamin D to prevent calcification of the heart.

Reducing Nutrient Absorption 

On the other hand, there may be certain parts of your diet that can reduce vitamin and mineral absorption. Although there are many health benefits in drinking coffee and other caffeinated beverages, caffeine is known to block the absorption of calcium, magnesium and iron (7). As little as one cup of coffee a day has been show to reduce mineral absorption. So if you are going to drink coffee try to make sure you drink it at a time other than when eating food or taking supplements.

Furthermore, phytates found in grains and nuts can also reduce nutrient absorption, too. High phytate intake reduces the absorption of calcium, zinc and iron, which can lead to a whole range of adverse effects in the body. Dr. Loren Cordain, author of the original Paleo Diet book (8), as well as other nutritional scientists, believe that phytates are a major contributing factor in the worldwide epidemic of iron-deficiency anemia, as well as deficiency in zinc (9).

In order to benefit from a range of different nutrients, it is important for you to eat a varied diet, and a simple way to ensure this is to make sure that you eat from a wide range of different kinds of unprocessed food. A good starting point for an excellent diet is by varying the colors on your plate. Aim for 5 different colors of foods on your plate, with added variations in the types of meat, fish and poultry you routinely consume. Of course, PurePharma-3 can also help to provide you with a diverse range of synergistic vitamins and minerals to maximize the benefits of healthy eating. 


  1. Jacobs, David R., Myron D. Gross, and Linda C. Tapsell. “Food synergy: an operational concept for understanding nutrition.” The American journal of clinical nutrition 89.5 (2009): 1543S-1548S.
  2. http://www.vitamindcouncil.org/about-vitamin-d/vitamin-d-and-other-vitamins-and-minerals/
  3. Seo, Hyun-Ju, et al. “Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells.” Nutrition research and practice 4.5 (2010): 356-361.
  4. Saggese, G., et al. “Bone demineralization and impaired mineral metabolism in insulin-dependent diabetes mellitus. A possible role of magnesium deficiency.” Helvetica paediatrica acta 43.5-6 (1989): 405-414.
  5. De Souza, Miriam C., et al. “A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study.” Journal of women’s health & gender-based medicine 9.2 (2000): 131-139.
  6. BOURNE, HENRY R., and G. M. ToMKINS. “Zinc: a trace element essential in vitamin A metabolism.” Proc. Nat. Acad. Sci. USA 69 (1972): 459.
  7. Massey, Linda K., et al. “Interactions between dietary caffeine and calcium on calcium and bone metabolism in older women.” Journal of the American College of Nutrition 13.6 (1994): 592-596.
  8. Cordain, Loren. The Paleo Diet Revised: Lose Weight and Get Healthy by Eating the Foods You Were Designed to Eat. Houghton Mifflin Harcourt, 2010.
  9. Reinhold, John G. “High phytate content of rural Iranian bread: a possible cause of human zinc deficiency.” The American journal of clinical nutrition 24.10 (1971): 1204-1206.

 This blog was originally published on www.purepharma.com by Ryan Carey.